Standardized Volume Dosing Protocol of 23.4% Hypertonic Saline for Pediatric Critical Care: Initial Experience:

摘要: Background: Standardized volume dosing of 23.4% hypertonic saline (HTS) exists for adults, but the concentration, and administration HTS in pediatrics is variable. With emerging pediatric experience HTS, a standard dose approach may be helpful. Objective: To describe initial with standardized weight-based protocol 10, 20, or 30 mL intensive care unit. Methods: Standard doses were developed from weight equivalents 3% HTS. Pre post sodium intracranial pressure (ICP) measurements compared paired t-test Wilcoxon rank-sum test. The site complications noted. Results: A total 16 patients received 37 smallest patient weighing 11 kg. For compliance, 17 (46%) followed recommended dosing, 19 less than (51%), 1 (3%) was more recommended. Mean increase 3.5 mEq/L (95% CI = 2-5 mEq/L); P < 0.0001. median decrease ICP 10.5 mm Hg (interquartile range [IQR] 8.3-19.5) 37% (IQR 25%-64%) reduction. Most administered through central venous access, although peripheral intravenous administrations occurred 4 without complication. Conclusion Relevance: Three standard-volume options based on increases reduces patients. Standard-volume simplify storage emergencies, optimum dose, safety children remains unknown.