Impairment of cellular immunity in west Greenland sledge dogs (Canis familiaris) dietary exposed to polluted minke whale (Balaenoptera acutorostrata) blubber.

作者: Christian Sonne , Rune Dietz , Hans J. S. Larsen , Klaus Earl Loft , Maja Kirkegaard

DOI: 10.1021/ES052151D

关键词:

摘要: Minke whale (Balaenoptera acutorostrata) blubber is rich in organohalogen contaminants, mercury, and n-3 fatty acids. In the present study we show that a daily intake of 50-200 g minke causes an impairment nonspecific specific cellular immune system West Greenland sledge dog (Canis familiaris). Immune reactions were measured by mitogen (PHA, Con A) antigen (KLH) intradermal testing, as used exposure levels similar to those Inuits polar bears (Ursus maritimus), it reasonable infer suffer from decreased resistance diseases. It speculated food sources are depleted thinning sea ice due climate change more research should assess forecasted rise additive immunopathy effects bears. Additionally, our suggests acid composition may be importance when investigating combined immunotoxic contaminated resources future Inuit bear studies.

参考文章(36)
Christian Sonne, Rune Dietz, Erik W. Born, Frank F. Riget, Maja Kirkegaard, Lars Hyldstrup, Robert J. Letcher, Derek C. G. Muir, Is Bone Mineral Composition Disrupted by Organochlorines in East Greenland Polar Bears (Ursus Maritimus) Environmental Health Perspectives. ,vol. 112, pp. 1711- 1716 ,(2004) , 10.1289/EHP.7293
G. Weiss, F. Meyer, B. Matthies, M. Pross, W. Koenig, H. Lippert, Immunomodulation by perioperative administration of n-3 fatty acids. British Journal of Nutrition. ,vol. 87, ,(2002) , 10.1079/BJN2001461
Andrew E Derocher, Nicholas J Lunn, Ian Stirling, Polar Bears in a Warming Climate Integrative and Comparative Biology. ,vol. 44, pp. 163- 176 ,(2004) , 10.1093/ICB/44.2.163
L D Loose, J B Silkworth, K A Pittman, K F Benitz, W Mueller, Impaired host resistance to endotoxin and malaria in polychlorinated biphenyl- and hexachlorobenzene-treated mice. Infection and Immunity. ,vol. 20, pp. 30- 35 ,(1978) , 10.1128/IAI.20.1.30-35.1978
Jordi Folch, M. Lees, G.H. Sloane Stanley, A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES Journal of Biological Chemistry. ,vol. 226, pp. 497- 509 ,(1957) , 10.1016/S0021-9258(18)64849-5
Elisabeth Lie, Andrew E. Derocher, ⊘ystein Wiig, Stig Larsen, Richard Wiger, Janneche Utne Skaare, Irma C. Oskam, Erik Ropstad, Ellen Dahl, Organochlorines affect the major androgenic hormone, testosterone, in male polar bears (Ursus maritimus) at Svalbard. Journal of Toxicology and Environmental Health. ,vol. 66, pp. 2119- 2139 ,(2003) , 10.1080/15287390390211342
William R. Morrison, Lloyd M. Smith, Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol Journal of Lipid Research. ,vol. 5, pp. 600- 608 ,(1964) , 10.1016/S0022-2275(20)40190-7
C LYDERSEN, H WOLKERS, T SEVERINSEN, L KLEIVANE, E NORDOY, J SKAARE, Blood is a poor substrate for monitoring pollution burdens in phocid seals. Science of The Total Environment. ,vol. 292, pp. 193- 203 ,(2002) , 10.1016/S0048-9697(01)01121-4
Jennifer M Luross, Mehran Alaee, David B Sergeant, Christina M Cannon, D Michael Whittle, Keith R Solomon, Derek C.G Muir, Spatial distribution of polybrominated diphenyl ethers and polybrominated biphenyls in lake trout from the Laurentian Great Lakes. Chemosphere. ,vol. 46, pp. 665- 672 ,(2002) , 10.1016/S0045-6535(01)00230-2