The impact of prenatal insults on the human placental epigenome: A systematic review.

摘要: Abstract The placenta is the first human organ to reach full development during pregnancy. It serves as a barrier but also an interchange surface. Epigenetic changes observed in placental tissue may reflect intrauterine insults while pointing physiological pathways altered under exposure such environmental threats. By means of systematic search literature, 39 papers assessing epigenetic signatures association with either (i) psychosocial stress, (ii) maternal psychopathology, (iii) smoking pregnancy, and (iv) pollutants, were identified. Their findings revealed unique source variability that does not correlate patterns or newborn blood, tissues which are typically analyzed regarding prenatal stress. Studies stress psychopathology pregnancy scarce exploratory nature revealing inconsistent findings. Of note, there was marked tendency towards hypomethylation studies tobacco use pollutants suggesting interaction between contaminant-derived metabolites machinery. This review highlights need for further prospective longitudinal long-term health effects derived from several stressors.