Branched-chain amino acid and branched-chain ketoacid ingestion increases muscle protein synthesis rates in vivo in older adults: a double-blind, randomized trial.
作者： Cas J Fuchs , Wesley J H Hermans , Andrew M Holwerda , Joey S J Smeets , Joan M Senden
DOI: 10.1093/AJCN/NQZ120
关键词:
摘要: Background Protein ingestion increases muscle protein synthesis rates. However, limited data are currently available on the effects of branched-chain amino acid (BCAA) and ketoacid (BCKA) postprandial Objective The aim this study was to compare impact ingesting 6 g BCAA, BCKA, 30 milk (MILK) rise in circulating concentrations subsequent myofibrillar rates older males. Methods In a parallel design, 45 males (age: 71 ± 1 y; BMI: 25.4 0.8 kg/m2) were randomly assigned ingest drink containing or MILK. Basal assessed by primed continuous l-[ring-13C6]phenylalanine infusions with collection blood samples biopsies. Results Plasma BCAA increased following test all groups, greater MILK groups compared BCKA group (P 0.05). Myofibrillar during late phase (2-5 h) remained elevated (0.039 0.004%/h; P Conclusions Ingestion early (0-2 vivo healthy increase is short-lived, higher only being maintained an equivalent amount intact protein. This trial registered at Nederlands Trial Register (www.trialregister.nl) as NTR6047.
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