Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma
作者： Stefan Nagel , Corinna Meyer , Maren Kaufmann , Hans G. Drexler , Roderick A.F. MacLeod
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摘要: In Hodgkin lymphoma (HL) we recently identified deregulated expression of homeobox genes MSX1 and OTX2 which are physiologically involved in development the embryonal neural plate border region. Here, examined HL gene SIX1 an additional regulator this region mediating differentiation placodal precursors. was aberrantly activated 12 % patient samples silico, indicating a pathological role subset B-cell malignancy. addition, detected cell lines were used as models to reveal upstream factors target basic developmental regulator. We increased copy numbers locus at chromosome 14q23 correlating with enhanced while chromosomal translocations absent. Moreover, comparative profiling data pertinent modulation experiments indicated that WNT-signalling pathway transcription factor MEF2C regulate expression. Genes encoding GATA2, GATA3, SPIB – all lymphoid regulators - targets HL. cofactors EYA1 TLE4, respectively, contrastingly mediated activation suppression Thus, protein domain interfaces may represent therapeutic SIX1-positive subsets. Collectively, our regulatory network centrally deregulating support concordance lymphopoiesis/lymphomagenesis processes
impactjournals.com参考文章(61)
Jasna Medvedovic, Anja Ebert, Hiromi Tagoh, Meinrad Busslinger, Pax5: A Master Regulator of B Cell Development and Leukemogenesis Advances in Immunology. ,vol. 111, pp. 179- 206 ,(2011) , 10.1016/B978-0-12-385991-4.00005-2
Roderick A. F. MacLeod, Maren Kaufmann, Hans G. Drexler, Cytogenetic Analysis of Cancer Cell Lines Methods of Molecular Biology. ,vol. 731, pp. 57- 78 ,(2011) , 10.1007/978-1-61779-080-5_6
Sally A Moody, Anthony-Samuel LaMantia, None, Transcriptional regulation of cranial sensory placode development Current Topics in Developmental Biology. ,vol. 111, pp. 301- 350 ,(2015) , 10.1016/BS.CTDB.2014.11.009
Kimberly L. Christensen, Aaron N. Patrick, Erica L. McCoy, Heide L. Ford, Chapter 5 The Six Family of Homeobox Genes in Development and Cancer Advances in Cancer Research. ,vol. 101, pp. 93- 126 ,(2008) , 10.1016/S0065-230X(08)00405-3
Stefan Nagel, Corinna Meyer, Maren Kaufmann, Hans G. Drexler, Roderick A. F. MacLeod, Deregulated FOX genes in Hodgkin lymphoma. Genes, Chromosomes and Cancer. ,vol. 53, pp. 917- 933 ,(2014) , 10.1002/GCC.22204
JJM van Dongen, EA Macintyre, JA Gabert, E Delabesse, V Rossi, G Saglio, E Gottardi, A Rambaldi, G Dotti, F Griesinger, A Parreira, P Gameiro, M González Diáz, M Malec, AW Langerak, JF San Miguel, A Biondi, Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia. ,vol. 13, pp. 1901- 1928 ,(1999) , 10.1038/SJ.LEU.2401592
Marit E. Hystad, June H. Myklebust, Trond H. Bø, Einar A. Sivertsen, Edith Rian, Lise Forfang, Else Munthe, Andreas Rosenwald, Michael Chiorazzi, Inge Jonassen, Louis M. Staudt, Erlend B. Smeland, Characterization of early stages of human B cell development by gene expression profiling Journal of Immunology. ,vol. 179, pp. 3662- 3671 ,(2007) , 10.4049/JIMMUNOL.179.6.3662
Jun-Yuan Chen, The sudden appearance of diverse animal body plans during the Cambrian explosion The International Journal of Developmental Biology. ,vol. 53, pp. 733- 751 ,(2009) , 10.1387/IJDB.072513CJ
Ralf Küppers, The biology of Hodgkin's lymphoma Nature Reviews Cancer. ,vol. 9, pp. 15- 27 ,(2009) , 10.1038/NRC2542
B Argiropoulos, R K Humphries, Hox genes in hematopoiesis and leukemogenesis Oncogene. ,vol. 26, pp. 6766- 6776 ,(2007) , 10.1038/SJ.ONC.1210760