Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production.

摘要: Neoalbaconol, derived from Albatrellus confluens, shows anti-cancer activities in the previously study, but its role angiogenesis is unknown. Here, we determined whether neoalbaconol could attenuate and how does it occur. Data demonstrated that inhibit proliferation of breast cancer cells induce apoptosis. Also, suppressed vascular endothelial growth factor (VEGF)-induced human umbilical (HUVECs) proliferation, migration, invasion, capillary-like tube formation vitro reduced tumor vivo. VEGF receptor activation downstream signal transduction cascades were inhibited by neoalbaconol. Additionally, blocked EGFR-mediated production. EGFR overexpression reversed neoalbaconol-induced reduction, confirming importance inhibition anti-angiogenesis Furthermore, a xenograft model Taken together, these results indicate through direct suppression effects on reduction proangiogenic factors cells.