Mathematical model of depolarization mechanism of conducted vasoreactivity

摘要: We address the problem of conducted vasodilation, phenomenon which is also known as functional hyperemia. Specifically, we test mechanism nondecremental propagation electric signals along endothelial cell layer recently hypothesized by Figueroa et al. By means modeling focus on possible nonlinear mechanisms that can underlie such regenerative pulse transmission (RPT). Since cells (EC) are generally electrically inexcitable, role ECs in RPT not evident. mathematical check dynamical self-consistency Figueroa's hypothesis, well estimate contribution specific ionic currents to suggested mechanism.