Unactivated C(sp(3))-H hydroxylation through palladium catalysis with H2O as the oxygen source.
作者： Jiantao Hu , Tianlong Lan , Yihua Sun , Hui Chen , Jiannian Yao
DOI: 10.1039/C5CC04952K
关键词:
摘要: A novel palladium catalyzed hydroxylation of unactivated aliphatic C(sp(3))-H bonds was successfully developed. Different from conventional methods, water serves as the hydroxyl group source in reaction. This new reaction demonstrates good reactivity and broad functional tolerance. The C-H hydroxylated products can be readily transformed into various highly valuable chemicals via known transformations. Based on experimental theoretical studies, a mechanism involving Pd(II)/(IV) pathway is proposed for this
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