Shaping the repertoire of tumor-infiltrating effector and regulatory T cells

摘要: Many tumors express antigens that can be specifically or selectively recognized by T lymphocytes, suggesting T-cell-mediated immunity may harnessed for the immunotherapy of cancer. However, since originate from normal cells and evolve within context self-tissues, immune mechanisms prevent autoimmune attack tissues function in parallel to restrict anti-tumor immunity. In particular, purging autoreactive development immune-suppressive regulatory (Tregs) are thought major barriers impeding responses. Here, we discuss current understanding regarding tumor-infiltrating T-cell populations, shape repertoire these cells, role transcription factor regulator (Aire) processes. Further elucidation principles is likely critical optimizing emerging cancer immunotherapies, rational design novel therapies exhibiting robust activity with limited toxicity.