The human hepatic cytochromes P450 involved in drug metabolism.
作者： Steven A. Wrighton , Jeffrey C. Stevens
DOI: 10.3109/10408449209145319
关键词:
摘要: The cytochromes P450 are a superfamily of hemoproteins that catalyze the metabolism large number xenobiotics and endobiotics. type amount (i.e., animal's phenotype) P450s expressed by animal, primarily in liver, thus determine metabolic response animal to chemical challenge. A majority characterized involved hepatic drug have been identified experimental animals. However, recently at least 12 human drug-metabolizing molecular and/or enzyme level. characterization these has made it possible "phenotype" microsomal samples with respect their relative levels various capabilities. purpose this review is compare contrast related forms rat other species.
informapharmascience.com参考文章(171)
David J. Waxman, Cynthia Attisano, F.Peter Guengerich, David P. Lapenson, Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme Archives of Biochemistry and Biophysics. ,vol. 263, pp. 424- 436 ,(1988) , 10.1016/0003-9861(88)90655-8
Raija L. P. Lindberg, Masahiko Negishi, Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue. Nature. ,vol. 339, pp. 632- 634 ,(1989) , 10.1038/339632A0
Dene E. Ryan, Wayne Levin, Purification and characterization of hepatic microsomal cytochrome P-450 Pharmacology & Therapeutics. ,vol. 45, pp. 153- 239 ,(1990) , 10.1016/0163-7258(90)90029-2
Gunilla Ekström, Christer von Bahr, Magnus Ingelman-Sundberg, Human liver microsomal cytochrome P-450IIE1. Imnunological evaluation of its contribution to microsomal ethanol oxidation, carboti tetrachloride reduction and NADPH oxidase activity Biochemical Pharmacology. ,vol. 38, pp. 689- 693 ,(1989) , 10.1016/0006-2952(89)90217-7
Örjan Mortimer, Kerstin Persson, Margarita G Ladona, David Spalding, Urs M Zanger, Urs A Meyer, Anders Rane, Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1. Clinical Pharmacology & Therapeutics. ,vol. 47, pp. 27- 35 ,(1990) , 10.1038/CLPT.1990.4
Jerome M. Lasker, Judy Raucy, Shinji Kubota, Barbara P. Bloswick, Martin Black, Charles S. Lieber, Purification and characterization of human liver cytochrome P-450-ALC. Biochemical and Biophysical Research Communications. ,vol. 148, pp. 232- 238 ,(1987) , 10.1016/0006-291X(87)91100-4
U. Thomas Meier, Urs A. Meyer, Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency. Biochemistry. ,vol. 26, pp. 8466- 8474 ,(1987) , 10.1021/BI00399A065
Steven A. Wrighton, Paul E. Thomas, David T. Molowa, Mitsuru Haniu, John E. Shively, Sarah L. Maines, Paul B. Watkins, George Parker, Gerald Mendez-Picon, Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase Biochemistry. ,vol. 25, pp. 6731- 6735 ,(1986) , 10.1021/BI00370A001
Kaoru Aida, Masahiko Negishi, Posttranscriptional regulation of coumarin 7-hydroxylase induction by xenobiotics in mouse liver: mRNA stabilization by pyrazole. Biochemistry. ,vol. 30, pp. 8041- 8045 ,(1991) , 10.1021/BI00246A023
Judy L. Raucy, Jerome M. Lasker, Charles S. Lieber, Martin Black, Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2 Archives of Biochemistry and Biophysics. ,vol. 271, pp. 270- 283 ,(1989) , 10.1016/0003-9861(89)90278-6