Caudal neostigmine with bupivacaine produces a dose-independent analgesic effect in children

作者: Rajesh Mahajan , Vinod K. Grover , Pramila Chari

DOI: 10.1007/BF03018429

关键词:

摘要: Purpose: To evaluate the analgesic efficacy and duration of varying doses caudal neostigmine with plain bupivacaine its side effects in children undergoing genito-urinary surgery. Methods: In a randomized double-blind prospective study 80 boys aged two to eight years scheduled for surgical repair hypospadias were allocated randomly one four groups (n = 20 each) received either only 0.25% 0.5 mL·kg –1 (Group I) or (Groups II–IV) 2, 3 4 µg·kg respectively. Postoperative pain was assessed 24 hr using an objective score. Blood pressure, heart rate, oxygen saturation, total amount consumed adverse also

参考文章(30)
L Marion, E T Iwamoto, Characterization of the antinociception produced by intrathecally administered muscarinic agonists in rats. Journal of Pharmacology and Experimental Therapeutics. ,vol. 266, pp. 329- 338 ,(1993)
David D. Hood, James C. Eisenach, Robin Tuttle, Phase I Safety Assessment of Intrathecal Neostigmine Methylsulfate in Humans Anesthesiology. ,vol. 82, pp. 331- 343 ,(1995) , 10.1097/00000542-199502000-00003
Gabriela R. Lauretti, David D. Hood, James C. Eisenach, Ben L. Pfeifer, A Multi-center Study of Intrathecal Neostigmine for Analgesia following Vaginal Hysterectomy Anesthesiology. ,vol. 89, pp. 913- 918 ,(1998) , 10.1097/00000542-199810000-00016
Elliot J. Krane, Lawrence E. Jacobson, Anne M. Lynn, Carol Parrot, Donald C. Tyler, Caudal morphine for postoperative analgesia in children: a comparison with caudal bupivacaine and intravenous morphine. Anesthesia & Analgesia. ,vol. 66, pp. 647- 653 ,(1987) , 10.1213/00000539-198707000-00012
Herve Bouaziz, Chuanyao Tong, James C. Eisenach, Postoperative analgesia from intrathecal neostigmine in sheep. Anesthesia & Analgesia. ,vol. 80, pp. 1140- 1144 ,(1995) , 10.1097/00000539-199506000-00012
Jyrson G. Klamt, Marlene P. Dos Reis, José Barbieri Neto, Wiliam A. Prado, Analgesic effect of subarachnoid neostigmine in two patients with cancer pain. Pain. ,vol. 66, pp. 389- 391 ,(1996) , 10.1016/0304-3959(96)03045-X
Bernard Dalens, Regional anesthesia in children Anesthesia & Analgesia. ,vol. 68, pp. 654- 672 ,(1989) , 10.1213/00000539-198905000-00020
Sumio Hoka, Daniel Siker, Zeljko J. Bosnjak, John P. Kampine, Alteration of Blood Flow Distribution and Vascular Capacitance during Induced Hypotension in Deafferented Dogs Anesthesiology. ,vol. 66, pp. 647- 652 ,(1987) , 10.1097/00000542-198705000-00009
A. C. Senel, A. Akyol, D. Dohman, M. Solak, Caudal bupivacaine-tramadol combination for postoperative analgesia in pediatric herniorrhaphy. Acta Anaesthesiologica Scandinavica. ,vol. 45, pp. 786- 789 ,(2001) , 10.1034/J.1399-6576.2001.045006786.X