An efficient access to β-ketosulfones via β-sulfonylvinylamines: metal–organic framework catalysis for the direct C–S coupling of sodium sulfinates with oxime acetates

摘要: A copper-based framework Cu2(OBA)2(BPY) was synthesized and used as a recyclable heterogeneous catalyst for the synthesis of β-sulfonylvinylamines from sodium sulfinates oxime acetates via direct C–S coupling reaction. The transformation remarkably affected by solvent, chlorobenzene emerged best option. This Cu-MOF displayed higher activity than numerous conventional homogeneous MOF-based catalysts. reutilized many times in without considerably deteriorating catalytic efficiency. These were readily converted to corresponding β-ketosulfones hydrolysis step with aqueous HCl solution. To our knowledge, this reaction achieve not previously conducted catalyst.