Stimulation of protooncogene expression by partial hepatectomy is not tissue-specific.

摘要: We have characterized the early protooncogene response and later cell proliferative in kidneys livers of normal rats cross-circulated with partially hepatectomized animals. Increase c-myc C-Ha-ras expression was observed totally rats, as well those their partners. This indicates that initial to hepatectomy is not organ-specific, although DNA synthetic kidney only approximately one-tenth regenerating liver. Expression c-Ha-ras dramatically increased both nonhepatectomized, parabiotic (cross-circulated) within 1 hr partial hepatectomy, confirming presence a circulating factor which stimulates regeneration. synthesis also stimulated animals between 20 26 following but level one-eighth Normal demonstrated an increase hepatic expression, indicating regeneration must be by extrahepatic signal. Our data suggest non-organ-specific does insure subsequent cellular proliferation. The organ specificity liver involve event separate from stimulation expression.