The emerging normal and disease-related roles of anaplastic lymphoma kinase.

摘要: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, the normal role of which remains to be completely elucidated. Although work carried out in mammals suggests function neural development, results from studies Drosophila indicate an additional visceral muscle differentiation. The aberrant expression full-length ALK proteins has been reported neuroblastomas and glioblastomas, while occurrence fusion anaplastic large cell (ALCL) resulted identification new tumor entity, ALK-positive ALCL. represents one few examples implicated oncogenesis both haematopoietic non-haematopoietic tumors, given that fusions also occur mesenchymal known as inflammatory myofibroblastic (IMT). study proteins, besides demonstrating their importance raised possibility therapeutic treatments for patients with malignancies.