Inflammation and increased myxovirus resistance protein A expression in thyroid tissue in the early stages of Hashimoto's thyroiditis
作者： Sara Salehi Hammerstad , Frode Lars Jahnsen , Sisko Tauriainen , Heikki Hyöty , Trond Paulsen
关键词:
摘要: Background: The role of viruses as environmental triggers for Hashimoto's thyroiditis (HT) is controversial. Thyroid epithelial cells express a variety molecules involved in antiviral responses. This study combined histological, immunological, and virological tests to describe changes tissue from patients with newly diagnosed untreated HT. To the early events, positive thyroid peroxidase antibodies (TPO-Ab) normal function were also included. stage was defined “prethyroiditis.” Methods: collected 47 high titers TPO-Ab 24 controls. Seventeen had prethyroiditis, 17 subclinical hypothyroidism, 13 overt hypothyroidism. interferon (IFN)-α/β-inducible myxovirus resistance protein 1 (myxovirus A; MxA) used surrogate marker type I IFN expression. Inflammation, expression MxA, presence enteroviralcapsid (VP1) characterized by imm...
sci-hub.se 参考文章(42)
Rachel Desailloud, Anne Goffard, Cyril Page, Benoit Kairis, Stéphanie Fronval, Denis Chatelain, Vladimir Strunski, Alain Dubreuil, Didier Hober, Detection of enterovirus RNA in postoperative thyroid tissue specimens. Clinical Endocrinology. ,vol. 70, pp. 331- 334 ,(2009) , 10.1111/J.1365-2265.2008.03331.X
M. Oikarinen, S. Tauriainen, T. Honkanen, S. Oikarinen, K. Vuori, K. Kaukinen, I. Rantala, M. Mäki, H. Hyöty, Detection of enteroviruses in the intestine of type 1 diabetic patients Clinical and Experimental Immunology. ,vol. 151, pp. 71- 75 ,(2008) , 10.1111/J.1365-2249.2007.03529.X
Nagako Akeno, Eric P. Smith, Mihaela Stefan, Amanda K. Huber, Weijia Zhang, Mehdi Keddache, Yaron Tomer, IFN-α Mediates the Development of Autoimmunity both by Direct Tissue Toxicity and through Immune Cell Recruitment Mechanisms The Journal of Immunology. ,vol. 186, pp. 4693- 4706 ,(2011) , 10.4049/JIMMUNOL.1002631
PAOLO AIRÒ, CLAUDIA GHIDINI, CINZIA ZANOTTI, MIRKO SCARSI, ROBERTO CATTANEO, LUIGI CAIMI, LUISA IMBERTI, Upregulation of myxovirus-resistance protein A: a possible marker of type I interferon induction in systemic sclerosis. The Journal of Rheumatology. ,vol. 35, pp. 2192- 2200 ,(2008) , 10.3899/JRHEUM.080418
Rachel Desailloud, Didier Hober, Viruses and thyroiditis: an update. Virology Journal. ,vol. 6, pp. 5- 5 ,(2009) , 10.1186/1743-422X-6-5
Jamie C. Mandac, Sonal Chaudhry, Kenneth E. Sherman, Yaron Tomer, The clinical and physiological spectrum of interferon-alpha induced thyroiditis: Toward a new classification† Hepatology. ,vol. 43, pp. 661- 672 ,(2006) , 10.1002/HEP.21146
Iwona Ben-Skowronek, Leszek Szewczyk, Roman Ciechanek, Elzbieta Korobowicz, Interactions of Lymphocytes, Thyrocytes and Fibroblasts in Hashimoto’s Thyroiditis: An Immunohistochemical and Ultrastructural Study Hormone Research in Paediatrics. ,vol. 76, pp. 335- 342 ,(2011) , 10.1159/000331857
Roland J. Baur, Jack R. Wall, Horst Schleusener, Isolation and characterization of mononuclear cells from various thyroid tissue specimens. Life Sciences. ,vol. 32, pp. 55- 65 ,(1983) , 10.1016/0024-3205(83)90173-X
Patricia R. Hutchings, Suman Verma, Jenny M. Phillips, Silvia Zusman Harach, Sarah Howlett, Anne Cooke, Both CD4+T Cells and CD8+T Cells Are Required for Iodine Accelerated Thyroiditis in NOD Mice Cellular Immunology. ,vol. 192, pp. 113- 121 ,(1999) , 10.1006/CIMM.1998.1446
Hartwig W. Lehmann, Nicola Lutterbüse, Annelie Plentz, Ilker Akkurt, Norbert Albers, Berthold P. Hauffa, Olaf Hiort, Eckhard Schoenau, Susanne Modrow, Association of Parvovirus B19 Infection and Hashimoto's Thyroiditis in Children Viral Immunology. ,vol. 21, pp. 379- 383 ,(2008) , 10.1089/VIM.2008.0001