Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer.

摘要: Objective Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. Design RG analysis was conducted by a multidisciplinary panel of patients, clinicians researchers (n=71). Eight working groups (WG) were constituted: discovery science; risk; prevention; early diagnosis screening; pathology; curative treatment; stage IV disease; living with beyond CRC. A series discussions led development draft papers each WG, which evaluated 20-strong panel. final list RGs recommendations (RR) endorsed all participants. Results Fifteen are summarised below: RG1 : Lack realistic models that recapitulate tumour/tumour micro/macroenvironment; RG2 Insufficient evidence on precise contributions genetic/environmental/lifestyle factors CRC RG3 Pressing need for prevention trials; RG4 integration different approaches; RG5 optimal strategies RG6 effective triage systems invasive investigations; RG7 Imprecise pathological assessment CRC; RG8 qualified personnel in genomics, data sciences digital RG9 Inadequate assessment/communication risk, benefit uncertainty treatment choices; RG10 Need novel technologies/interventions outcomes; RG11 approaches recognise molecular interplay between metastasising tumours microenvironment; RG12 reliable biomarkers guide RG13 increase understanding health related quality life (HRQOL) promote residual symptom resolution; RG14 coordination research/funding; RG15 communication relevant stakeholders. Conclusion Prioritising activity funding have impact reducing disease burden over the next 5 years.