Pharmacologic attenuation of cross-modal sensory augmentation within the chronic pain insula.

摘要: Pain can be elicited through all mammalian sensory pathways yet cross-modal integration, and its relationship to clinical pain, is largely unexplored. Centralized chronic pain conditions such as fibromyalgia are often associated with symptoms of multisensory hypersensitivity. In this study, female patients demonstrated hypersensitivity visual pressure stimuli compared age- sex-matched healthy controls. Functional magnetic resonance imaging revealed that insular activity evoked by an aversive level stimulation was the intensity pain. Moreover, attenuation analgesic pregabalin accompanied concomitant reductions in A multivariate classification method using support vector machines (SVM) applied visual-evoked brain distinguished from controls 82% accuracy. separate SVM treatment effects on reliably identified when were administered placebo. Both analyses significant weights within cortex during stimulation. These data suggest abnormal integration insula may represent a pathophysiological mechanism some response have utility marker for drug development.