Nafamostat mesilate attenuates transient focal ischemia/reperfusion-induced brain injury via the inhibition of endoplasmic reticulum stress
作者： Sun Kwan Kwon , Moonsang Ahn , Hee-Jung Song , Shin Kwang Kang , Saet-Byel Jung
DOI: 10.1016/J.BRAINRES.2015.09.013
关键词:
摘要: Nafamostat mesilate (NM), a serine protease inhibitor, has broad range of clinical applications that include use as an anticoagulant during hemodialysis in cerebral hemorrhage patients, hemoperfusion for patients with intravascular coagulation, hemorrhagic lesions, and tendencies, the improvement acute pancreatitis. However, effects NM on ischemia have yet to be investigated. Thus, present study utilized rat model which transient middle artery occlusion (MCAO) was used induce ischemic injury investigate infarct volume histological biological changes. (1mg/kg) intravenously administered prior after MCAO procedure. Compared control rats, administration significantly decreased size extent brain edema induction focal via MCAO. Additionally, treatment attenuated MCAO-induced neuronal degeneration activation microglia astrocytes. also inhibited expression levels glucose-regulated protein 78 (GRP78), CATT/EBP homologous (CHOP), p-eukaryotic initiation factor 2α (eIF2α), are endoplasmic reticulum (ER) stress markers, cortex. The findings demonstrate exerts neuroprotective following via, at least part, inhibition ER stress.
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