Impact of combination therapy on disease free survival in hypopharynx cancer
作者： Helma Maria Chedid , Sergio Altino Franzi , Abrão Rapoport , Otávio Alberto Curioni
DOI: 10.1590/S0100-69912010000600002
关键词:
摘要: OBJECTIVE: To evaluate the disease-free survival in hypopharyngeal tumors submitted to postoperative radiotherapy. METHODS: we retrospectively studied 174 patients with following distribution: two cases of stage I, four II, 46 III and 122 IV. Regarding gender, 163 were male 11 female; mean age was 56 years. All underwent pharyngolaryngectomy; neck dissections radical 206 selective 16. One hundred six radiotherapy, a dose 58.2 Gy. RESULTS: Histological examination showed pT1, 15 pT2, 100 pT3 57 pT4. As for lymph nodes, 25 had no involvement (pN0); 149 presented node invasion (pN +). Five-year 40% overall 28%. According results histological examination, five-year 75% clinical versus 28% IV. CONCLUSION: The initial manifestation squamous cell carcinoma hypopharynx happens advanced stages (III IV), superior III.
sci-hub.se 参考文章(24)
Pen-Yuan Chu, Wing-Yin Li, Shyue-Yih Chang, Clinical and Pathologic Predictors of Survival in Patients with Squamous Cell Carcinoma of the Hypopharynx after Surgical Treatment Annals of Otology, Rhinology, and Laryngology. ,vol. 117, pp. 201- 206 ,(2008) , 10.1177/000348940811700307
William I. Wei, The dilemma of treating hypopharyngeal carcinoma: more or less: Hayes Martin Lecture. Archives of Otolaryngology-head & Neck Surgery. ,vol. 128, pp. 229- 232 ,(2002) , 10.1001/ARCHOTOL.128.3.229
Aijaz Alvi, Jonas T. Johnson, Development of distant metastasis after treatment of advanced-stage head and neck cancer Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 19, pp. 500- 505 ,(1997) , 10.1002/(SICI)1097-0347(199709)19:6<500::AID-HED7>3.0.CO;2-2
Chiu Ming Ho, Kam Hing Lam, William Ignace Wei, Po Wing Yuen, Lai Kun Lam, Squamous cell carcinoma of the hypopharynx--analysis of treatment results. Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 15, pp. 405- 412 ,(1993) , 10.1002/HED.2880150507
C. Vandenbrouck, F. Eschwege, A. La De Rochefordiere, H. Sicot, G. Mamelle, A. M. Le Ridant, J. Bosq, C. Domenge, Squamous cell carcinoma of the pyriform sinus: Retrospective study of 351 cases treated at the institut Gustave‐Roussy Head & Neck Surgery. ,vol. 10, pp. 4- 13 ,(1987) , 10.1002/HED.2890100103
C. M. LALANNE, Y. CACHIN, G. JUILLARD, R. LEFUR, Telecobalt therapy for carcinoma of laryngopharynx. American Journal of Roentgenology. ,vol. 111, pp. 78- 84 ,(1971) , 10.2214/AJR.111.1.78
A. G. D. Maran, P. M. Stell, Head and neck surgery ,(1972)
Peter C. G. Wahlberg, K. E. Harald Andersson, Anders T. Biörklund, Torgil R. Möller, Carcinoma of the hypopharynx: Analysis of incidence and survival in Sweden over a 30-year period Head & Neck. ,vol. 20, pp. 714- 719 ,(1998) , 10.1002/(SICI)1097-0347(199812)20:8<714::AID-HED9>3.0.CO;2-2
J. L. Lefebvre, B. Castelain, J. C. La De Torre, A. Delobelle-Deroide, B. Vankemmel, Lymph node invasion in hypopharynx and lateral epilarynx carcinoma: a prognostic factor. Head & Neck Surgery. ,vol. 10, pp. 14- 18 ,(1987) , 10.1002/HED.2890100104
J.-L. Lefebvre, D. Chevalier, B. Luboinski, A. Kirkpatrick, L. Collette, T. Sahmoud, Larynx Preservation in Pyriform Sinus Cancer: Preliminary Results of a European Organization for Research and Treatment of Cancer Phase III Trial Journal of the National Cancer Institute. ,vol. 88, pp. 890- 899 ,(1996) , 10.1093/JNCI/88.13.890