Motor Experience Reprograms Development of a Genetically-Altered Bilateral Corticospinal Motor Circuit

摘要: Evidence suggests that motor experience plays a role in shaping development of the corticospinal system and voluntary control, which is key function system. Here we used mouse model with conditional forebrain deletion gene for EphA4 (Emx1-Cre:EphA4tm2Kldr), regulates laterality tract (CST). We combined study Emx1-Cre:EphA4tm2Kldr unilateral forelimb constraint during to expand our understanding experience-dependent CST from both basic translational perspectives. This develops dense ipsilateral projections, bilateral cortex representation, phenotypes. Together these phenotypes can be as readouts organization changes brought about by experience. The shares features common developmental disorder cerebral palsy: impairments miswiring. mice typical experiences display phenotype “mirror” reaching, because strongly representation CST. By contrast, experienced P1 P30 tested at maturity had more contralateral each hemisphere; lateralized projections; substantially lateralized/independent reaching movements. Changes this explained reduced synaptic competition side without experiences. Using show largely abrogated effects genetic mutation on projections thus demonstrates how robust persistent establishment connections control. Further, findings inform mechanisms strategies developing behavioral therapies treat movement miswiring palsy.