DNA Saline Solutions Near Surfaces

摘要: DNA hybridization occurs with different equilibrium constants and kinetics when near surfaces as opposed to in homogeneous saline solution. Thus melting temperatures are shifted by the presence of a surface. Much effort has gone into understanding The goal this article is review current molecular picture salt solution which consistent known experimental thermodynamic kinetic data. Calculations simple models have been used an attempt make most direct possible comparisons recent structural biological/biochemical experiments. In particular research relevance microarray technologies where nucleic acid probes immobilized on duplexes formed target strands We present overview experiments, theories computer simulations relevant surfaces.