Comparative antioxidant, antiproliferative and phase II enzyme inducing potential of sorghum (Sorghum bicolor) varieties.

摘要: Abstract Epidemiological evidence has linked consumption of sorghum with reduced incidences gastrointestinal cancer, especially cancer esophagus. No information is available on how may effect the chemoprotective properties. We investigated in vitro potential eight varieties to induce phase II detoxifying enzymes using NAD(P)H:quinone oxidoreductase (NQO) enzyme assay, and also inhibit proliferation esophageal, OE33, colon, HT-29, carcinoma cells PicoGreen 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays; these properties were compared phenolic profile antioxidant activity sorghum. Black extract high 3-deoxyanthocyanins was most potent NQO inducer, doubling at 5.0 μg/mL maximally inducing by 3.0 times. White a moderately strong increasing 80%; tannin-containing sorghums non-inducers. On other hand, extracts had strongest antiproliferative against both OE33 HT-29 (IC50, 38–105 μg/mL); white least 389–>800 μg/mL). Antiproliferative correlated whereas NQO-inducer capacity did not. Sorghum have which partially independent their They thus be valuable health-promoting ingredients whole-grain based products.