Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI.

摘要: Purpose: Cerebrovascular reactivity (CVR) is an index of the dilatory function cerebral blood vessels and has shown great promise in diagnosis risk factors cerebrovascular disease. Aging one such factor; thus, it important to characterize age-related differences CVR. CVR can be measured by BOLD MRI but few studies have quantitative flow (CBF)-based context aging. This study aims determine age effect on using two CBF techniques, phase-contrast (PC), arterial spin labeling (ASL) MRI. Methods: In 49 participants (32 younger 17 older), was with PC, ASL, These methods were compared across young older groups their dependence age. PC ASL also studied for inter-correlation mean differences. Gray white matter values studied. Results: higher than (by 17%, p = 0.046). However, there no or significantly correlated (p 0.042) 0.016), its underestimated 0.045). map revealed difference between gray tissue types, whereas map. Conclusion: techniques brain aging that a more sensitive method detection differences, despite absence spatial information. The showed significant correlation BOLD, tends underestimate due confounding associated this technique. Importantly, our data suggest not CBF-based matter, contrast previous observation