摘要: 1.1. Introduction Although assessing DNA methy-lation has not yet become commonplace in the diagnostic molecular pathology laboratory, many tests involving methyla-tion analysis will part of routine practice. In this chapter, a practical approach be taken toward evaluating methylation. The principal question likely to asked laboratory is whether specific gene or region methylated pathological situation; for example, MLH1 promoter colorectal cancer specimen showing microsatellite instability? This chapter deal with methods that examine sequences rather than those examining total genomic methylation screening new sites recurrent
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