Requirement of Hos2 Histone Deacetylase for Gene Activity in Yeast
作者： Amy Wang , Siavash K Kurdistani , Michael Grunstein
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摘要: Histone deacetylases, typified by class I Rpd3 in the yeast Saccharomyces cerevisiae, have historically been associated with gene repression. We now demonstrate that Hos2, another member of family, binds to coding regions genes primarily during activation, when it specifically deacetylates lysines H3 and H4 histone tails. Moreover, Hos2 is preferentially high activity genome-wide. also show an factor, Set3, are necessary for efficient transcription. Therefore, our data indicate that, contrast other directly required activation.
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T G Turi, J C Loper, Multiple regulatory elements control expression of the gene encoding the Saccharomyces cerevisiae cytochrome P450, lanosterol 14 alpha-demethylase (ERG11). Journal of Biological Chemistry. ,vol. 267, pp. 2046- 2056 ,(1992) , 10.1016/S0021-9258(18)46051-6
Stephen E. Rundlett, Andrew A. Carmen, Noriyuki Suka, Bryan M. Turner, Michael Grunstein, Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature. ,vol. 392, pp. 831- 835 ,(1998) , 10.1038/33952
Maria Vogelauer, Jiansheng Wu, Noriyuki Suka, Michael Grunstein, Global histone acetylation and deacetylation in yeast Nature. ,vol. 408, pp. 495- 498 ,(2000) , 10.1038/35044127
Mark S. Longtine, Amos Mckenzie III, Douglas J. Demarini, Nirav G. Shah, Achim Wach, Arndt Brachat, Peter Philippsen, John R. Pringle, Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae Yeast. ,vol. 14, pp. 953- 961 ,(1998) , 10.1002/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U
JamesG. Yargera, HarlynO. Halvorson, JamesE. Hopper, Regulation of galactokinase (GAL1) enzyme accumulation in Saccharomyces cerevisiae Molecular and Cellular Biochemistry. ,vol. 61, pp. 173- 182 ,(1984) , 10.1007/BF00222494
Birgitte Ø Wittschieben, Gabriel Otero, Therese de Bizemont, Jane Fellows, Hediye Erdjument-Bromage, Reiko Ohba, Yang Li, C.David Allis, Paul Tempst, Jesper Q Svejstrup, A Novel Histone Acetyltransferase Is an Integral Subunit of Elongating RNA Polymerase II Holoenzyme Molecular Cell. ,vol. 4, pp. 123- 128 ,(1999) , 10.1016/S1097-2765(00)80194-X
Vishwanath R Iyer, Christine E Horak, Charles S Scafe, David Botstein, Michael Snyder, Patrick O Brown, None, Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF Nature. ,vol. 409, pp. 533- 538 ,(2001) , 10.1038/35054095
David Kadosh, Kevin Struhl, Repression by Ume6 Involves Recruitment of a Complex Containing Sin3 Corepressor and Rpd3 Histone Deacetylase to Target Promoters Cell. ,vol. 89, pp. 365- 371 ,(1997) , 10.1016/S0092-8674(00)80217-2
Noriyuki Suka, Yuko Suka, Andrew A Carmen, Jiansheng Wu, Michael Grunstein, Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin. Molecular Cell. ,vol. 8, pp. 473- 479 ,(2001) , 10.1016/S1097-2765(01)00301-X
Birgitte Ø Wittschieben, Jane Fellows, Wendy Du, David J Stillman, Jesper Q Svejstrup, Overlapping roles for the histone acetyltransferase activities of SAGA and elongator in vivo. The EMBO Journal. ,vol. 19, pp. 3060- 3068 ,(2000) , 10.1093/EMBOJ/19.12.3060