CCR3, CCR5, interleukin 4, and interferon-gamma expression on synovial and peripheral T cells and monocytes in patients with rheumatoid arthritis.

摘要: OBJECTIVE: To characterize cytokine and chemokine receptor profiles of T cells monocytes in inflamed synovium peripheral blood (PB) patients with rheumatoid arthritis (RA) other arthritides. METHODS: We studied PB synovial fluid (SF) samples taken from 20 RA 9 8 healthy adults were used as controls. CCR3, CCR5, intracellular interferon-g (IFN-g) interleukin 4 (IL-4) expression CD8+ CD8- cell populations CD14+ determined flow cytometry. RESULTS: Expression CCR5 CCR3 by CD8-, was increased SF compared to The number spontaneously expressing IL-4 IFN-g higher than patients. Spontaneous associated derived RA. In the ratio CCR5+/CCR3+ after mitogen stimulation controls arthritides CONCLUSION: infiltrating joints showed activation both type 1 2 immune markers. More pronounced response joints, shown an CCR5/CCR3 ratio, found versus those Monocytes but not