Evaluation of oxidative metabolism and oxidative DNA damage in patients with obsessive-compulsive disorder.
作者： Demet Alici , Feridun Bulbul , Osman Virit , Ahmet Unal , Abdurrahman Altindag
DOI: 10.1111/PCN.12362
关键词:
摘要: Aims There are limited published data about the role of oxidative stress in pathophysiology obsessive–compulsive disorder (OCD). In addition, and DNA damage have not been investigated together OCD. this study, we aimed to evaluate patients with OCD. Methods Forty-two OCD who were diagnosed Psychiatry Clinic Gaziantep University 38 healthy volunteers enrolled study. Serum 8-hydroxideoxiguanosine (8-OHdG), total antioxidant status, oxidant status evaluation index calculation conducted Biochemical Laboratory. Results There no significant differences levels between control group. However, 8-OHdG significantly higher than controls (P = 0.022). lower took treatment newly (P = 0.016). Conclusions In our found that increased even though was normal. treated compared those without treatment.
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