Effect of Sub-Chronic Administration of Tetracera potatoria Roots Extract and Betulinic Acid from the Plant on Haematology and Serum Biochemistry of Wistar Rats

摘要: Tetracera potatoria is used as natural remedy for a wide range of diseases in West Africa. Anti-ulcerogenic and anti inflammatory effects T. potatoria  are reported to be induced by Betulinic acid (BA). This study was aimed at assessment the safety  and BA using acute sub-chronic toxicity methods. Methanol extract root (100, 500 1000 mg/kg) (10, 20 40 isolated from the extract were administered Wistar rats 28 consecutive days in subchronic toxicity study. Each experiment had control groups (n=5) which with distilled water (10ml/kg). Whole blood and serum samples collected the rats hematology serum biochemistry on day 29. significant decreases PCV 42.8±1.5% (control) 32.7±2.2% (1000mg/kg) 6 RBC 12.8±0.4 X10 /μl to 6 11.6±9.1X10 /μl, but increased WBC 3 levels 7.8±2.3 (control) to 3 9.1±1.2 (500mg/kg). BA induced decreases from 42.8±1.2% 41.8±0.4%, RBC 6 12.7±7.6X10 6.1±1.1 6 /μl. Serum biochemistry showed significant increases ALT  48.5±2.2 U/L 66.75±12.5 rats (40mg/kg), relatively normal AST. Triglyceride non-significantly reduced treated 74.0±3.8 mg/dl 139.3±4.8 (40 mg/kg). In conclusion, sub-acute administration of root nontoxic, but showed more toxicity cells tendency to cause dyslipidemia. Keywords: , Betulinic acid, haematology,