Acute myocardial infarction with lung cancer during treatment with gefitinib: the possibility of gefitinib-induced thrombosis.

摘要: administration of gefi tinib was then started. A good response observed but with a grade 1–2 skin adverse toxicity ( table 1 , period A). Two months later she complained severe fatigue, and electrocardiography (ECG) revealed ischemic changes B). She diagnosed acute myocardial infarction. Therefore, the halted. On admission day, ECG sinus rhythm an ST elevation in leads V 1–3 T wave inversion 3–6 fi g. ). However, there were neither ndings nor abnormalities laboratory tests over next 24 h C). other hand, echocardiographic consistent diagnosis infarction left anterior descending area. After 2 weeks’ observation, restarted under continued treatment aspirin D). Following about tinib, minor lung cancer observed. An analysis platelet aggregation, stimulated by ADP or collagen before after weeks receiving performed. Both collagen-induced aggregations suppressed restart tinib. both exhibited tendency towards enhancement