Lipases and (R)-oxynitrilases: useful tools in organic synthesis

作者: Vicente Gotor

DOI: 10.1016/S0168-1656(02)00035-4

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摘要: The use of enzymes in organic solvents is currently special relevance for the preparation products high added value. Lipases are that have shown greatest utility through enzymatic transesterification reactions. Over last few years, we value aminolysis and ammonolysis reactions amides resolution esters amines. We alkoxycarbonylation also great chemoselective natural products. Lyases, much less exploited synthesis, proving increasingly interesting, especially (R)-oxynitrilases synthesis optically active cyanohydrins.

参考文章(40)
Vicente Gotor, Enzymatic Aminolysis and Ammonolysis Reactions Springer Netherlands. pp. 117- 132 ,(2000) , 10.1007/978-94-010-0924-9_6
B. Zwanenburg, Piotr Kiełbasiński, Marian Mikołajczyk, Enzymes in Action Green Solutions for Chemical Problems ,(2008)
Kathryn M. Koeller, Chi-Huey Wong, Enzymes for chemical synthesis Nature. ,vol. 409, pp. 232- 240 ,(2001) , 10.1038/35051706
María Jesús García, Francisca Rebolledo, Vicente Gotor, Chemoenzymatic aminolysis and ammonolysis of β-ketoesters Tetrahedron Letters. ,vol. 34, pp. 6141- 6142 ,(1993) , 10.1016/S0040-4039(00)61751-3
Ignacio Alfonso, Covadonga Astorga, Francisca Rebolledo, Vicente Gotor, OPTICALLY ACTIVE TETRAAZAMACROCYCLES ANALOGOUS TO CYCLAM Tetrahedron-asymmetry. ,vol. 10, pp. 2515- 2522 ,(1999) , 10.1016/S0957-4166(99)00232-3
Maria I Monterde, Serge Nazabadioko, Francisca Rebolledo, Rosario Brieva, Vicente Gotor, Chemoenzymatic synthesis of azacycloalkan-3-ols Tetrahedron-asymmetry. ,vol. 10, pp. 3449- 3455 ,(1999) , 10.1016/S0957-4166(99)00351-1
Robert Chênevert, Ghodsi Mohammadi Ziarani, Marie Pascale Morin, Mohammed Dasser, Enzymatic desymmetrization of meso cis-2,6- and cis,cis-2,4,6-substituted piperidines. Chemoenzymatic synthesis of (5S,9S)-(+)-indolizidine 209D Tetrahedron-asymmetry. ,vol. 10, pp. 3117- 3122 ,(1999) , 10.1016/S0957-4166(99)00315-8
Ignacio Alfonso, Francisca Rebolledo, Vicente Gotor, Optically Active Dioxatetraazamacrocycles: Chemoenzymatic Syntheses and Applications in Chiral Anion Recognition Chemistry - A European Journal. ,vol. 6, pp. 3331- 3338 ,(2000) , 10.1002/1521-3765(20000915)6:18<3331::AID-CHEM3331>3.0.CO;2-8
Francisco Morís, Vicente Gotor, Lipase-mediated alkoxycarbonylation of nucleosides with oxime carbonates. Tetrahedron. ,vol. 48, pp. 9869- 9876 ,(1992) , 10.1016/S0040-4020(01)92279-3