Extracellular vesicles as an emerging mechanism of cell-to-cell communication.
作者： Ciro Tetta , Ezio Ghigo , Lorenzo Silengo , Maria Chiara Deregibus , Giovanni Camussi
DOI: 10.1007/S12020-012-9839-0
关键词:
摘要: The concept that extracellular vesicles may act as paracrine/endocrine effectors is based on the evidence they are able to transport bioactive molecules between cells, either within a defined microenvironment or remotely, by entering biologic fluids. Extracellular vesicles, including exosomes and microvesicles, deliver lipids various functional transcripts, released from cell of origin, target cells. Since contain patterns mRNA, microRNA, long non-coding RNA, occasionally genomic DNA, transfer genetic information which induces transient persistent phenotypic changes in recipient In this review, we will discuss potential physiologic pathological implications well diagnostic therapeutic opportunities provide.
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