Systematic review of the efficacy of non-pharmacological interventions in people with Lewy body dementia.

摘要: ABSTRACTBackground:Pharmacological interventions for Lewy body dementia (LBD), especially its non-cognitive symptoms, are limited in their efficacy and tolerability. Clinicians often uncertain about non-pharmacological managing cognitive symptoms of LBD. Therefore, we aimed to systematically review the existing literature on people with Methods We carried out a systematic search using six databases. All human studies examining impact any intervention LBD were assessed cognitive, physical, psychiatric, quality-of-life outcomes. Study quality was by Effective Public Health Practice Project Quality Assessment Tool Quantitative Studies CARE criteria checklist. Results Prevailing evidence supporting is weak. screened 1,647 papers. Fifteen (n = 61) including 11 case reports found eligible this review. Interventions reported outcomes heterogeneous. Deep brain stimulation nucleus basalis Meynert reportedly conferred benefit. Electroconvulsive therapy repetitive transcranial magnetic have been ameliorate depressive symptoms. Transcranial direct current observed improve attention. Exercise-based various clinically important Spaced retrieval memory training environmental "mirror sign" also reported. Conclusions Several studied Although not robust, prevailing preliminary limitations available pharmacological indicate need consider appropriate interventions, while planning comprehensive care patients. Larger trials evaluating needed.