Genetic and epigenetic changes associated with cholangiocarcinoma: From DNA methylation to microRNAs
作者： Monique Stutes , Steven Tran , Sharon DeMorrow
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摘要: Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about molecular development of this disease, very few effective treatment options available. Thus, prognosis poor. Genetic epigenetic changes play an integral role in neoplastic transformation human cells to their counterparts. This review summarizes some more prevalent genetic alterations (by microRNA expression) (hypermethylation specific gene promoters) that thought contribute carcinogenic process cholangiocarcinoma.
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