Characterization of two novel Ly-6 genes. Protein sequence and potential structural similarity to alpha-bungarotoxin and other neurotoxins.

摘要: Genomic clones cross-hybridizing with Ly-6A.2 cDNA were isolated and characterized for functional Ly-6-related genes. Two new Ly-6 genes, designated Ly-6F.1 Ly-6G.1, found to have high nucleotide homology (> or = 70%) the characteristic four exon gene organization of Ly-6A/E Ly-6C. By a PCR-based assay, Ly-6G.1 mRNA was readily in bone marrow, whereas not detected lymphoid tissues. Thus, represents an additional apparent selective expression hematopoietic cells distinct from Using available deduced protein sequence data mature proteins, searches database uncovered evolutionary relationship proteins neurotoxins snake venoms. The conservation between two groups for, but limited to, residues that been be important their tertiary structures. From this relationship, we propose neurotoxin-like structure such as CD59.