Treatment resistant schizophrenia is associated with the worst community functioning among severely-ill highly-disabling psychiatric conditions and is the most relevant predictor of poorer achievements in functional milestones.

摘要: The aim of this work was to compare achievements in milestones community functioning highly disabling psychiatric conditions, including treatment resistant schizophrenia (TRS), (responsive antipsychotics), bipolar disorder, and anxiety/depressive diseases. Also, we investigated the predictors outcomes across several domains. Among consecutive patients screened, 188 met inclusion criteria 118 ultimately entered study. Diagnosis TRS made by stringent criteria, historic perspective evaluations excluding potential confounding factors. Achievements functional everyday living were recorded. Performances discrete cognitive tasks assessed. Positive Negative Syndrome Scale, Personal Social Performance Drug Attitude Inventory-10, Quality Life Enjoyment Satisfaction Questionnaire administered. showed highest impairment among diagnostic groups. found have more severe psychopathology, impaired functioning, poorer psychosocial adjustment compared all other In whole sample, main group (with diagnosis associated with worst functioning) milestones. psychotic patients, however, clinical psychopathological variables. These results may support hypothesis that represents a separate subtype, its own neurobiology, psychopathology course. Our identify modifiable be addressed prevent disability.