Global forebrain dynamics predict rat behavioral states and their transitions.

摘要: The wake-sleep cycle, a spontaneous succession of global brain states that correspond to major overt behaviors, occurs in all higher vertebrates. transitions between these states, at once rapid and drastic, remain poorly understood. Here, intracranial local field potentials (LFPs) recorded the cortex, hippocampus, striatum, thalamus were used characterize neurophysiological correlates rat cycle. By way new method for objective classification quantitative investigation we demonstrate state occur simultaneously across multiple forebrain areas as specific spectral trajectories with characteristic path, duration, coherence bandwidth. During transitions, striking changes neural synchronization are effected by prominent narrow-band LFP oscillations mark boundaries. Our results distant tightly coordinate processing information during indicating very high degree functional integration entire We propose transient oscillatory synaptic inputs, which underlie switching may facilitate exchange within boundaries distinct regimens.