Small airway pathology is related to increased closing capacity and abnormal slope of phase III in excised human lungs.

摘要: Single-breath nitrogen and static pressure-volume curves were obtained from 29 excised human lungs. The lungs separated into 2 groups based on values predicted for closing capacity; “normal” (n = 19) had normal capacities, “abnormal” 10) capacities that larger than normal. Closing pressure (the at the onset of capacity) differed between groups. group abnormal a higher mean (2.25 cm H2O) (0.98 (p < 0.01). A grading system was used to estimate extent pathologic changes in small airways each whole lung. Mural inflammation squamous metaplasia lesions significantly degree 0.05) Data both combined determine whether any variables examined correlated with data single-breath curves. Among airway lesi...