Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

摘要: Background/Objectives: Motor impairment induced by traumatic brain injury (TBI) may be mediated through changes in spinal molecular systems regulating neuronal plasticity. We assessed whether a focal controlled cortical impact (CCI) TBI the rat alters expression of Tgfb1, c-Fos, Bdnf, and Gap43 neuroplasticity genes lumbar cord. Approach/Methods: Adult male Sprague-Dawley rats (n = 8) were subjected to right-side CCI over anterior sensorimotor hindlimb representation area or sham-injury 8). Absolute levels Gapd43 measured droplet digital PCR ipsi-and contralesional, dorsal ventral quadrants L4 L5 The activity marker c-Fos was analysed immunohistochemistry segments. contra- vs. ipsilesional pattern examined as asymmetry index, AI. Results: Tgfb1 mRNA significantly higher sham-injured rats, domains group. number c-Fos-positive cells elevated segments; on contralesional compared side AI laminae increased CCI. Conclusions: results support hypothesis that induces plastic alterations cord contribute either motor recovery maladaptive responses. (Less)