Adjuvant systemic treatment for elderly breast cancer patients; addressing safety concerns.

作者: Omar Abdel-Rahman , Hesham ElHalawani

DOI: 10.1517/14740338.2014.955848

关键词:

摘要: Introduction: The issue of systemic treatment for early breast cancer in the elderly has always been challenging and spite clear evidence potential benefits adjuvant older women, they are usually undertreated with consequence worse outcomes. Areas covered: This article will review surrounding various options armamentarium early-stage patients. risks benefits, particular attention to a number newly introduced targeted agents, along role incorporating combined geriatric/oncologic assessment as routine part management patients considered. Expert opinion: Administration available (neo)adjuvant endocrine, chemo, well therapeutics fit is feasible tolerable; however, input from geriatric medicine psycho-oncology experts training o...

参考文章(135)
Gilles Albrand, Catherine Terret, Early breast cancer in the elderly: assessment and management considerations. Drugs & Aging. ,vol. 25, pp. 35- 45 ,(2008) , 10.2165/00002512-200825010-00004
Anita Stewart, Caren Kamberg, Physical Functioning Measures Duke University Press. ,(1992)
Villars H, Guigoz Y, Garry P, Morley Je, Vellas B, Rolland Y, Rubenstein Lz, Salva A, Chumlea W, Soto Me, Abellan G, Overview of the MNA--Its history and challenges. Journal of Nutrition Health & Aging. ,vol. 10, pp. 456- 465 ,(2006)
Ashwin Woodhoo, Marta Varela-Rey, Shelly C Lu, Maria-Luz Martinez-Chantar, José M Mato, Alcohol, DNA methylation, and cancer. Alcohol Res , 35 (1) pp. 25-35. (2013). ,vol. 35, pp. 25- 35 ,(2013)
Anita Stewart, John Ware, Measuring Functioning and Well-Being: The Medical Outcomes Study Approach Duke University Press. ,(1992) , 10.7249/CB361
Olga H. Torres, Jose Muñoz, Domingo Ruiz, Josep Ris, Ignasi Gich, Eva Coma, Mercè Gurguí, Guillermo Vázquez, Outcome predictors of pneumonia in elderly patients: importance of functional assessment. Journal of the American Geriatrics Society. ,vol. 52, pp. 1603- 1609 ,(2004) , 10.1111/J.1532-5415.2004.52492.X
Ludwik Branski, Andreas Jokuszies, Robert Krämer, Peter M. Vogt, Christopher Betzler, Christine Radtke, Is tamoxifen associated with an increased risk for thromboembolic complications in patients undergoing microvascular breast reconstruction GMS German Medical Science. ,vol. 11, ,(2013) , 10.3205/000173
Prakash Narain, Laurence Z. Rubenstein, G. Darryl Wieland, Brad Rosbrook, L. Sandra Strome, Fern Pietruszka, John E. Morley, Predictors of Immediate and 6-Month Outcomes in Hospitalized Elderly Patients Journal of the American Geriatrics Society. ,vol. 36, pp. 775- 783 ,(1988) , 10.1111/J.1532-5415.1988.TB04259.X
Soo Borson, James M. Scanlan, Peijun Chen, Mary Ganguli, The Mini‐Cog as a Screen for Dementia: Validation in a Population‐Based Sample Journal of the American Geriatrics Society. ,vol. 51, pp. 1451- 1454 ,(2003) , 10.1046/J.1532-5415.2003.51465.X
Teresa E. Seeman, Lisa F. Berkman, Frank Kohout, Andrea Lacroix, Robert Glynn, Dan Blazer, Intercommunity variations in the association between social ties and mortality in the elderly: A comparative analysis of three communities Annals of Epidemiology. ,vol. 3, pp. 325- 335 ,(1993) , 10.1016/1047-2797(93)90058-C