Breath metabolite response to major upper gastrointestinal surgery

摘要: Abstract Background Esophagectomy and gastrectomy are associated with profound metabolic changes significant postoperative morbidity. The aim of this prospective clinical study was to determine whether breath analysis can offer novel insight into the surgical response identify biomarkers complications, including lung injury. Methods Breath samples were collected preoperatively at 24, 48, 72, 96 168 h after esophagectomy ( n  = 25)  = 15). Targeted four prominent metabolites performed by selected ion flow-tube mass spectrometry. Patients nonsurgical injury (community-acquired pneumonia) recruited as positive controls. Results Perioperative starvation subsequent reintroduction nutritional input in acetone levels. levels fell P  = 0.008) significantly lower than patients time points 48  = 0.014). Pneumonia most frequently observed complication (esophagectomy 36% 7%). concentration hydrogen cyanide who developed pneumonia, 72 h surgery  = 0.008). Exhaled  = 0.001) isoprene  = 0.014) also reduced community-acquired pneumonia compared healthy Conclusions Selected spectrometry be used a totally noninvasive resource monitor multiple aspects alterations period. concentrations several altered major upper gastrointestinal pneumonia.