Mutagenic Activity of Chemical Carcinogens and Related Compounds in the Intraperitoneal Host-Mediated Assay

摘要: The mutagenic activities of 79 carcinogens, noncarcinogens, and structurally related compounds toward Salmonella typhimurium strains TA1530, TA1535, TA1538 Saccharomyces cerevisiae D3 were investigated in the intraperitoneal host-mediated assay. Fewer than half carcinogens strains. insensitivity system was most marked with aromatic amine polycyclic hydrocarbon procarcinogens. Under test conditions, fewer 10% showed clear activity S. D3. However, none noncarcinogens significantly either or Overall, assay does not seem suitable for routine preliminary screening large numbers potential carcinogens. median lethal doses to mice 46 determined.