Hemodynamic Determinants of the Abnormal Cardiopulmonary Exercise Response in Heart Failure With Preserved Left Ventricular Ejection Fraction

摘要: Abstract Background The cardiopulmonary exercise testing (CPET) response in heart failure with preserved left ventricular ejection fraction (HFPEF) is incompletely understood. We aimed to describe the CPET HFPEF and assess its invasive hemodynamic determinants. Methods Results Ten patients 8 asymptomatic controls underwent resting right catheterization maximal symptom-limited CPET. slope of minute ventilation/carbon dioxide production relationship (VE/VCO 2 slope; 34.3 ± 5.4 vs. 28.4 ± 3.4; P  = .02) was steeper, peak oxygen consumption (peak VO ; 15.1 ± 4.9 26.6 ± 12.5 mL∗kg -1 ∗min lower, rate recovery 1 after termination (HRR-1; 10 ± 5 27 ± 10 beats/min; ( r  = 0.67,  = .002), lower  = −0.48,  = .04), slower HRR-1  = −0.58, were significantly related a higher ratio change pulmonary capillary wedge pressure per work as measure volume relationship. Conclusions In patients, fundamental alterations profile occur these may, part, result from rapid rise filling pressures which accompanies patients.