Guidelines for prudent use of antimicrobials and their implications on antibiotic usage in veterinary medicine.

摘要: Antibiotics are still deemed necessary for the treatment and prevention of infectious diseases in farm animals intended food production to protect public health from food-borne diseases. All antibiotics used veterinary medicine same or closely related antibacterials human may induce cross-resistance. Consumption figures European Union (EU) indicate an about 10-fold higher number days when compared usage with tetracyclines being most frequently group. However, conditions antibiotic use animals, mainly swine poultry by oral a large prolonged periods time risk underdosing might favour selection bacterial resistance. In order reduce thus minimize development resistance medicine, compulsory guidelines prudent were published Germany December 2000. These describe minimum requirements be followed veterinarians administering animals. Key elements on basis exact (preferentially microbiological) diagnosis, choice suitable antibacterial substance (antibacterial spectrum as narrow possible, margin safety high good tissue penetration if necessary), restricted last resort character, adherence label instructions (no prolongation dosing interval). Any deviations guideline recommendations must justified recorded. Results monitoring medicated feeding stuffs pig German state Sachsen-Anhalt October 2000 until March 2002 change prescribing attitude after implementation guidelines. The consumption continuously declined 4255 kg before 1145 first quarter resulting reduction per animal 31.6 (third 2000) 13.6 (first 2002). Simultaneously chlortetracycline decreased initially 76% total amount prescribed 14.7% at end study, respectively. results suggest acceptance important tool consecutive