Calcium-Binding Proteins

作者: Bryan E. Finn , Torbjörn Drakenberg

DOI: 10.1016/S0898-8838(08)60153-1

关键词:

摘要: Publisher Summary This chapter describes calcium-binding proteins. Calcium is of widespread and fundamental importance in biochemistry because the calcium ion functions as a second messenger—that is, one whose signals are propagated by proteins specifically evolved for this purpose. The divides (or protein domains) into: (1) intracellular, (2) mediated membrane bound, (3) extracellular. EF hand far most common motif intracellular calcium- binding It an approximately 30 amino acid long peptide chain composed central loop flanked two alpha helixes. Both nuclear magnetic resonance (NMR) spectroscopy X-ray crystallography played key roles understanding target calmodulin. functional role interactions with remain area intense study. One similar to calcyclin has been identified expressed predominantly brain.

参考文章(384)
P.A. Handford, M. Baron, M. Mayhew, A. Willis, T. Beesley, G.G. Brownlee, I.D. Campbell, The first EGF-like domain from human factor IX contains a high-affinity calcium binding site. The EMBO Journal. ,vol. 9, pp. 475- 480 ,(1990) , 10.1002/J.1460-2075.1990.TB08133.X
A.R. Rezaie, P.F. Neuenschwander, J.H. Morrissey, C.T. Esmon, Analysis of the functions of the first epidermal growth factor-like domain of factor X. Journal of Biological Chemistry. ,vol. 268, pp. 8176- 8180 ,(1993) , 10.1016/S0021-9258(18)53078-7
Z B Rose, J L Benovic, R K Gupta, Magnetic resonance studies of the binding of ATP and cations to human hemoglobin. Journal of Biological Chemistry. ,vol. 253, pp. 6165- 6171 ,(1978) , 10.1016/S0021-9258(17)34594-5
Sara Linse, Sture Forsén, Determinants that govern high-affinity calcium binding. Advances in second messenger and phosphoprotein research. ,vol. 30, pp. 89- 151 ,(1995) , 10.1016/S1040-7952(05)80005-9
N L Esmon, L E DeBault, C T Esmon, Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C. Journal of Biological Chemistry. ,vol. 258, pp. 5548- 5553 ,(1983) , 10.1016/S0021-9258(20)81925-5
C Valcarce, M Selander-Sunnerhagen, A M Tämlitz, T Drakenberg, I Björk, J Stenflo, Calcium affinity of the NH2-terminal epidermal growth factor-like module of factor X. Effect of the gamma-carboxyglutamic acid-containing module. Journal of Biological Chemistry. ,vol. 268, pp. 26673- 26678 ,(1993) , 10.1016/S0021-9258(19)74365-8
Anna FILIPEK, Urszula WOJDA, p30, a novel protein target of mouse calcyclin (S100A6) Biochemical Journal. ,vol. 320, pp. 585- 587 ,(1996) , 10.1042/BJ3200585
R J Grand, S V Perry, The binding of calmodulin to myelin basic protein and histone H2B Biochemical Journal. ,vol. 189, pp. 227- 240 ,(1980) , 10.1042/BJ1890227
Tom Blundell, Guy Dodson, Dorothy Hodgkin, Dan Mercola, Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by Advances in Protein Chemistry. ,vol. 26, pp. 279- 402 ,(1972) , 10.1016/S0065-3233(08)60143-6