作者: Bryan E. Finn , Torbjörn Drakenberg
DOI: 10.1016/S0898-8838(08)60153-1
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摘要: Publisher Summary This chapter describes calcium-binding proteins. Calcium is of widespread and fundamental importance in biochemistry because the calcium ion functions as a second messenger—that is, one whose signals are propagated by proteins specifically evolved for this purpose. The divides (or protein domains) into: (1) intracellular, (2) mediated membrane bound, (3) extracellular. EF hand far most common motif intracellular calcium- binding It an approximately 30 amino acid long peptide chain composed central loop flanked two alpha helixes. Both nuclear magnetic resonance (NMR) spectroscopy X-ray crystallography played key roles understanding target calmodulin. functional role interactions with remain area intense study. One similar to calcyclin has been identified expressed predominantly brain.