Metabolism of trichloroethylene in man

摘要: Volunteers inhaled a constant concentration of 50 ppm trichloroethylene (Tri) for 6 hrs per day on 5 consecutive days. Simultaneous ethanol (EtOH) ingestion (blood level 0.6 %.) inhibits the metabolization Tri to triehloroethanol (TCE) and trichloroacetic acid (TCA) by 40 % average. Oxidation TCA does not occur as long EtOH is present. During this time period blood Tri-concentration increases 21/2-fold, that in expired air rising 4-fold, compared inhalation without EtOH. TCE glucuronidation subject inhibition. On concurrent Tri, acetaldehyde levels are slightly increased over control values Tri. The mechanisms underlying alternate inhibition mixed-function oxygenases aldehyde dehydrogenase simultaneous intake discussed. intolerance reaction occurring combined exposure can be interpreted an accumulation CNS resulting from complete depression oxidation.