Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes
作者： MIRANG KIM , JONG-HWAN KIM , SU-JIN BAEK , SEON-YOUNG KIM , YONG SUNG KIM
关键词:
摘要: SLIT has been suggested as a key regulator of cancer development and promising therapeutic target for treatment. Herein, we analyzed expression methylation SLIT1/SLIT2/SLIT3 in 11 gastric cell lines, 96 paired tumors adjacent normal tissues, 250 cancers provided by The Cancer Genome Atlas. Methylation was found both early cancers, advanced cancers. Even tissue showed increased SLIT1 SLIT3 that correlated with patient age. Furthermore, epigenetic inactivation occurred subtype-dependent manner. SLIT2 reduced Epstein-Barr virus-positive microsatellite instability subtypes, but the genomically stable subtype. Expression miR‑218 negatively or SLIT3. These findings suggest molecular subtype-specific strategy is needed targeting SLITs miR-218 treatment cancer.
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