Vaccines containing salmonella bacteria attenuated by mutations in two genes of the aromatic amino acid biosynthetic pathway
作者： Steven Neville Chatfield , Carlos Estenio Hormaeche , Gordon Dougan
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摘要: An attenuated microorganism harbouring two mutated genes, each of which is located in the organisms aromatic pathway provided. These can usefully form basis a vaccine. They be genetically engineered so as to express antigens from other pathogens and thus range multi-valent vaccines.
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