Functional role of adrenomedullin (am) and the gene-related product (pamp) in human pathology and physiology
作者： Edward J. Unsworth , Charles Macri , Mae Jean Miller , Karen Gray , William A. Hook
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摘要: The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. provides for AM peptides antibodies useful therapeutic, pharmacologic physiologic compositions. additionally diagnosis, treatment prevention disease utilizing compositions comprising invention. also provide experimental models use identifying role pancreatic physiology. pertaining to rat isolated islets have shown inhibits insulin secretion dose-dependent manner. monoclonal antibody MoAb-G6, which neutralizes bioactivity, was by increase release fivefold, an effect reversed addition synthetic AM.
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