Etude thermoanalytique et lyodisponibilite de dispersions solides du tolbutamide
作者： A. Chauvet , J. Canotilho , A. T. B. de Sousa , J. Masse
DOI: 10.1007/BF02549920
关键词:
摘要: We have established the phase diagram tolbutamide (TBM)-PEG 6000 and determined eutectic composition 1/9 (w/w) in melting temperature 56.2 o C±0.3; no solid solution has been found. Negative mixing enthalpies of physical mixture (-2.5 J-g -1 ) dispersions coprecipitate (-3.9 melt (-9.9 for involve existence interactions between drug carrier. dissolution kinetics: amount % dissolved (10 min) 65.87±0.55 (physical mixture), 78.02±0.02 (coprecipitate), 99.9±0.10 (melt). observed a good agreement kinetics data
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