Corpus callosum in Alzheimer’s disease and vascular dementia — a quantitative magnetic resonance study

摘要: We investigated atrophic alterations in different regions of the corpus callosum Alzheimer’s disease (AD) and vascular dementia (VD) with respect to clinical changes. 32 patients AD (NINCDS-ADRDA criteria), 17 VD (NINDS-AIREN criteria) 13 healthy control subjects were included. 3-D MRI sequences acquired using a 1.5 T scanner. The size its subdivisions was sampled on 5 mid-saggital slices personal computer-based software. Total callosal significantly reduced but not VD. Furthermore, most rostral parts smaller when compared controls. Again, these changes found Severity correlated midbody AD. Callosal atrophy may reflect severity pattern cortical neuronal damage occurring mostly inferior frontal, anterior parietal midtemporal regions. Correlations between regional indicate that interhemispheric cortico-cortical disconnections contribute syndrome.